Isabel 6 - No connection with verification server or empty server response (45219)

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Check the local PC date & time settings:

The upload/download fails if these is too much difference between the time and date on the Isabel verification server and the user's date & time.
Folow this solution: The date and/or time on the PC differ too much from the date and time on the Isabel Server. What to do?

If the issue is not solved, consult your IT to proceed with the next steps